11 research outputs found
A nanoporous capacitive electrochemical ratchet for continuous ion separations
Directed ion transport in liquid electrolyte solutions underlies numerous
phenomena in nature and industry including neuronal signaling, photosynthesis
and respiration, electrodialysis for desalination, and recovery of critical
materials. Here, we report the first demonstration of an ion pump that drives
ions in aqueous electrolytes against a force using a capacitive ratchet
mechanism. Our ratchet-based ion pumps utilize the non-linear capacitive nature
of electric double layers for symmetry breaking which drives a net
time-averaged ion flux in response to a time varying input signal. Since the
devices are driven by a non-linear charging and discharging of double layers,
they do not require redox reactions for continual operation. Ratchet-based ion
pumps were fabricated by depositing thin gold layers on the two surfaces of
anodized alumina wafers, forming nanoporous capacitor-like structures. Pumping
occurs when a wafer is placed between two compartments of aqueous electrolyte
and the electric potential across it is modulated. In response to various input
signals, persistent ionic voltages and sustained currents were observed,
consistent with net unidirectional ion transport, even though conduction
through the membrane was non-rectifying. The generated ionic power was used in
conjunction with an additional shunt pathway to demonstrate electrolyte
demixing
Roadmap on semiconductor-cell biointerfaces.
This roadmap outlines the role semiconductor-based materials play in understanding the complex biophysical dynamics at multiple length scales, as well as the design and implementation of next-generation electronic, optoelectronic, and mechanical devices for biointerfaces. The roadmap emphasizes the advantages of semiconductor building blocks in interfacing, monitoring, and manipulating the activity of biological components, and discusses the possibility of using active semiconductor-cell interfaces for discovering new signaling processes in the biological world
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Development and Characterization of Ion Transport Systems and their Progress Toward Useful Applications
Ion transport systems are critical to many societal challenges, particularly in applications involved in aqueous environments where traditional electronics may not be as well suited. The production and directed movement of photo-generated species to produce useful energy, the transportation of ions to generate clean water through desalination, and the implementation of devices capable of seamlessly interfacing with biological systems for sensing or therapeutic purposes are a few of the many examples that use ion transport that aim to improve our daily lives. In this work, three independent projects will be showcased that touch on ion transport systems with these applications in mind. Our first materials innovation is analogous to an electronic semiconductor pn-junction that entails doping water using mineral salts and freezing the liquid water to immobilize counterions, thus forming doped polycrystalline solid protonic semiconductors. In this regard, we fabricate pn-junction ice cube diodes that demonstrate excellent current rectification properties. A second materials design innovation is a novel electronic ratchet that utilizes alternating electronic polarization to drive net ionic current. The system is unique in its ability to rely solely on interfacial charging to drive sustained direct currents and continuous ion separation. Lastly, the exploration of a previously underutilized proton conducting protein as a suitable culture substrate for neural stem/progenitor cells will be showcased. Recent work regarding potential cellular binding mechanisms and surface patterning will be discussed that contribute to the protein’s ever-expanding use in the bioelectronics field
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Reflectin as a Material for Neural Stem Cell Growth.
Cephalopods possess remarkable camouflage capabilities, which are enabled by their complex skin structure and sophisticated nervous system. Such unique characteristics have in turn inspired the design of novel functional materials and devices. Within this context, recent studies have focused on investigating the self-assembly, optical, and electrical properties of reflectin, a protein that plays a key role in cephalopod structural coloration. Herein, we report the discovery that reflectin constitutes an effective material for the growth of human neural stem/progenitor cells. Our findings may hold relevance both for understanding cephalopod embryogenesis and for developing improved protein-based bioelectronic devices
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Growth and Spatial Control of Murine Neural Stem Cells on Reflectin Films.
Stem cells have attracted significant attention due to their regenerative capabilities and their potential for the treatment of disease. Consequently, significant research effort has focused on the development of protein- and polypeptide-based materials as stem cell substrates and scaffolds. Here, we explore the ability of reflectin, a cephalopod structural protein, to support the growth of murine neural stem/progenitor cells (mNSPCs). We observe that the binding, growth, and differentiation of mNSPCs on reflectin films is comparable to that on more established protein-based materials. Moreover, we find that heparin selectively inhibits the adhesion of mNSPCs on reflectin, affording spatial control of cell growth and leading to a >30-fold change in cell density on patterned substrates. The described findings highlight the potential utility of reflectin as a stem cell culture material
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Growth and Spatial Control of Murine Neural Stem Cells on Reflectin Films.
Stem cells have attracted significant attention due to their regenerative capabilities and their potential for the treatment of disease. Consequently, significant research effort has focused on the development of protein- and polypeptide-based materials as stem cell substrates and scaffolds. Here, we explore the ability of reflectin, a cephalopod structural protein, to support the growth of murine neural stem/progenitor cells (mNSPCs). We observe that the binding, growth, and differentiation of mNSPCs on reflectin films is comparable to that on more established protein-based materials. Moreover, we find that heparin selectively inhibits the adhesion of mNSPCs on reflectin, affording spatial control of cell growth and leading to a >30-fold change in cell density on patterned substrates. The described findings highlight the potential utility of reflectin as a stem cell culture material
Reflectin as a Material for Neural Stem Cell Growth
Cephalopods possess remarkable camouflage
capabilities, which are
enabled by their complex skin structure and sophisticated nervous
system. Such unique characteristics have in turn inspired the design
of novel functional materials and devices. Within this context, recent
studies have focused on investigating the self-assembly, optical,
and electrical properties of reflectin, a protein that plays a key
role in cephalopod structural coloration. Herein, we report the discovery
that reflectin constitutes an effective material for the growth of
human neural stem/progenitor cells. Our findings may hold relevance
both for understanding cephalopod embryogenesis and for developing
improved protein-based bioelectronic devices